One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

Kanyama, Cecilia, Molloy, Síle, Chan, Adrienne K, Lupiya, Duncan, Chawinga, Chimwemwe, Adams, Jack, Bright, Philip, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Heyderman, Robert S, Lortholary, Olivier, Jaffar, Shabbar ORCID: https://orcid.org/0000-0002-9615-1588, Loyse, Angela, van Oosterhout, Joep J, Hosseinipour, Mina C and Harrison, Thomas (2020) 'One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi'. Clinical Infectious Diseases, Vol 70, Issue 3, pp. 521-524.

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Abstract

In Malawi, 236 participants from the ACTA cryptococcal meningitis treatment trial were followed-up for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericinB plus flucytosine was associated with the lowest 1 year mortality (27.5% [95%CI: 16.3 to 44.1]).

Item Type:	Article
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 252 Antifungal agents. Antifungal antibiotics QW Microbiology and Immunology > Fungi. Pathogenic Fungi. > QW 180 Pathogenic Fungi WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WL Nervous System > WL 200 Meninges. Blood-brain barrier
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1093/cid/ciz454
Depositing User:	Stacy Murtagh
Date Deposited:	05 Jun 2019 10:19
Last Modified:	23 Jan 2020 12:22
URI:	https://archive.lstmed.ac.uk/id/eprint/10954

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