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Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine.

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de Steenhuijsen Piters, Wouter A A, Jochems, Simon ORCID: https://orcid.org/0000-0002-4835-1032, Mitsi, Elena, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, Nikolaou, Elissavet, German, Esther, Holloway, Mark, Carniel, Beatriz, Chu, Mei Ling J N, Arp, Kayleigh, Sanders, Elisabeth A M, Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 and Bogaert, Debby (2019) 'Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine.'. Nature Communications, Vol 10, Issue 1, p. 2981.

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Abstract

Streptococcus pneumoniae is the main bacterial pathogen involved in pneumonia. Pneumococcal acquisition and colonization density is probably affected by viral co-infections, the local microbiome composition and mucosal immunity. Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge model. Nasal microbiota profiles at baseline are associated with consecutive pneumococcal carriage outcome (non-carrier, low-dense and high-dense pneumococcal carriage), independent of LAIV co-administration. Corynebacterium/Dolosigranulum-dominated profiles are associated with low-density colonization. Lowest rates of natural viral co-infection at baseline and post-LAIV influenza replication are detected in the low-density carriers. Also, we detected the fewest microbiota perturbations and mucosal cytokine responses in the low-density carriers compared to non-carriers or high-density carriers. These results indicate that the complete respiratory ecosystem affects pneumococcal behaviour following challenge, with low-density carriage representing the most stable ecological state.

Item Type: Article
Subjects: QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole.
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified)
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 210 Streptococcal infections (General or not elsewhere classified)
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1038/s41467-019-10814-9
Depositing User: Julie Franco
Date Deposited: 12 Jul 2019 09:58
Last Modified: 17 Sep 2019 08:54
URI: https://archive.lstmed.ac.uk/id/eprint/11189

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