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Nontuberculous mycobacterial adenitis: Effectiveness of chemotherapy following incomplete excision

Coulter, John B.S., Brian, J., Coulter, S., Lloyd, David A., Jones, Matthew, Cooper, John C., McCormick, Maxwell S., Clarke, Raymond W. and Tawil, Mohommed I. (2006) 'Nontuberculous mycobacterial adenitis: Effectiveness of chemotherapy following incomplete excision'. Acta Paediatrica, Vol 95, Issue 2, pp. 182-188.

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Abstract

Background: Management of lymphadenopathy caused by nontuberculous mycobacteria (NTM) is primarily surgical. Where this cannot achieve sufficient clearance of infected nodes, chemotherapy is often given. Aim: This study compared results of surgery alone with surgery followed by chemotherapy in instances where there was incomplete surgical removal of diseased tissue. Methods: Chemotherapy comprised azithromycin 10 mg/kg and rifabutin 6 mg/kg both given once daily for 6 mo. Ninety-eight children with NTM infection were seen in the period 1990-2004. Sixty-eight cases with adenopathy where "time to healing" (discharge stopped and inflammation settled) was known were available to compare response to treatment. Results : The median ( range) "time to healing" in weeks for 43 patients who had surgery alone was: incision and drainage (I&D)/curettage 6 (1-72) (n = 10); excision 3 (1-28) (n = 22); and from the last operation of multiple (repeat) surgery 3 (1-40) (n = 11). For 25 patients who required chemotherapy in addition to surgery, the median ( range) "time to healing" in weeks was I&D/curettage 10 (1-40) (n = 17), excision 14 (8-20) (n = 2) and multiple surgery 29 (2-88) (n = 6).
Conclusion: In children with adenitis due to NTM, where surgical resection is followed by continued discharge and inflammation, chemotherapy should be considered before further surgery is undertaken.

Item Type: Article
Additional Information: The definitive version is available at www3.interscience.wiley.com
Uncontrolled Keywords: atypical chemotherapy environmental mycobacteria lymphadenitis nontuberculous surgery atypical mycobacteria surgical-treatment avium complex lymph-nodes children lymphadenitis infection clarithromycin lymphadenopathy tuberculosis
Subjects: QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WH Hemic and Lymphatic Systems > Lymphatic System > WH 700 Lymphatic system. Lymphatic diseases (General)
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1651-2227.2006.tb02204.x
Depositing User: Martin Chapman
Date Deposited: 10 Feb 2011 13:49
Last Modified: 06 Feb 2018 13:01
URI: http://archive.lstmed.ac.uk/id/eprint/1464

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