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Coulter, John B.S., Brian, J., Coulter, S., Lloyd, David A., Jones, Matthew, Cooper, John C., McCormick, Maxwell S., Clarke, Raymond W. and Tawil, Mohommed I. (2006) 'Nontuberculous mycobacterial adenitis: Effectiveness of chemotherapy following incomplete excision'. Acta Paediatrica, Vol 95, Issue 2, pp. 182-188.
Full text not available from this repository.Abstract
Background: Management of lymphadenopathy caused by nontuberculous mycobacteria (NTM) is primarily surgical. Where this cannot achieve sufficient clearance of infected nodes, chemotherapy is often given. Aim: This study compared results of surgery alone with surgery followed by chemotherapy in instances where there was incomplete surgical removal of diseased tissue. Methods: Chemotherapy comprised azithromycin 10 mg/kg and rifabutin 6 mg/kg both given once daily for 6 mo. Ninety-eight children with NTM infection were seen in the period 1990-2004. Sixty-eight cases with adenopathy where "time to healing" (discharge stopped and inflammation settled) was known were available to compare response to treatment. Results : The median ( range) "time to healing" in weeks for 43 patients who had surgery alone was: incision and drainage (I&D)/curettage 6 (1-72) (n = 10); excision 3 (1-28) (n = 22); and from the last operation of multiple (repeat) surgery 3 (1-40) (n = 11). For 25 patients who required chemotherapy in addition to surgery, the median ( range) "time to healing" in weeks was I&D/curettage 10 (1-40) (n = 17), excision 14 (8-20) (n = 2) and multiple surgery 29 (2-88) (n = 6).
Conclusion: In children with adenitis due to NTM, where surgical resection is followed by continued discharge and inflammation, chemotherapy should be considered before further surgery is undertaken.
| Item Type: | Article |
|---|---|
| Additional Information: | The definitive version is available at www3.interscience.wiley.com |
| Uncontrolled Keywords: | atypical chemotherapy environmental mycobacteria lymphadenitis nontuberculous surgery atypical mycobacteria surgical-treatment avium complex lymph-nodes children lymphadenitis infection clarithromycin lymphadenopathy tuberculosis |
| Subjects: | QV Pharmacology > QV 38 Drug action. QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea WB Practice of Medicine > Therapeutics > WB 330 Drug therapy WH Hemic and Lymphatic Systems > Lymphatic System > WH 700 Lymphatic system. Lymphatic diseases (General) |
| Faculty: Department: | Groups (2002 - 2012) > Child & Reproductive Health Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1111/j.1651-2227.2006.tb02204.x |
| Depositing User: | Martin Chapman |
| Date Deposited: | 10 Feb 2011 13:49 |
| Last Modified: | 06 Feb 2018 13:01 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1464 |
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