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Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Jackson, J. A., Turner, Joseph, Kamal, M., Wright, V., Bickle, Q., Else, K. J., Ramsan, M. and Bradley, J. E. (2006) 'Gastrointestinal nematode infection is associated with variation in innate immune responsiveness'. Microbes and Infection, Vol 8, Issue 2, pp. 487-492.

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Abstract

Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

Item Type: Article
Uncontrolled Keywords: monocyte innate immunity human nematodiasis tlr4 tlr2 tnf-alpha il-10 tgf-beta necrosis-factor-alpha plasmodium-falciparum malaria vaccine cvd 103-hgr hepatitis-c virus ascaris-lumbricoides dendritic cells host-defense cytokine tlr4 mice
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QX Parasitology > Helminths. Annelida > QX 203 Nematoda
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 850 Nematode infections (General)
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.micinf.2005.07.025
Depositing User: Martin Chapman
Date Deposited: 26 May 2011 15:39
Last Modified: 06 Feb 2018 13:01
URI: https://archive.lstmed.ac.uk/id/eprint/1516

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