Jackson, J. A., Turner, Joseph ORCID: https://orcid.org/0000-0002-2185-5476, Kamal, M., Wright, V., Bickle, Q., Else, K. J., Ramsan, M. and Bradley, J. E. (2006) 'Gastrointestinal nematode infection is associated with variation in innate immune responsiveness'. Microbes and Infection, Vol 8, Issue 2, pp. 487-492.
Full text not available from this repository.Abstract
Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.
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