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Differentiating the pathologies of cerebral malaria by postmortem parasite counts

Taylor, T. E., Fu, W. J. J., Carr, R. A., Whitten, R. O., Mueller, J. G., Fosiko, N. G., Lewallen, S., Liomba, N. G. and Molyneux, Malcolm E (2004) 'Differentiating the pathologies of cerebral malaria by postmortem parasite counts'. Nature Medicine, Vol 10, Issue 2, pp. 143-145.

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Abstract

To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

Item Type: Article
Uncontrolled Keywords: falciparum-malaria african children
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 300 Hemic and lymphatic system
WW Ophthalmology > Eye Structures and their Diseases > WW 270 Retina
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1038/nm986
Depositing User: Martin Chapman
Date Deposited: 06 Jun 2012 15:33
Last Modified: 06 Feb 2018 13:03
URI: https://archive.lstmed.ac.uk/id/eprint/2211

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