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Taylor, T. E., Fu, W. J. J., Carr, R. A., Whitten, R. O., Mueller, J. G., Fosiko, N. G., Lewallen, S., Liomba, N. G. and Molyneux, Malcolm E (2004) 'Differentiating the pathologies of cerebral malaria by postmortem parasite counts'. Nature Medicine, Vol 10, Issue 2, pp. 143-145.
Full text not available from this repository.Abstract
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | falciparum-malaria african children |
| Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WS Pediatrics > Diseases of Children and Adolescents > By System > WS 300 Hemic and lymphatic system WW Ophthalmology > Eye Structures and their Diseases > WW 270 Retina |
| Faculty: Department: | Groups (2002 - 2012) > Clinical Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1038/nm986 |
| Depositing User: | Martin Chapman |
| Date Deposited: | 06 Jun 2012 15:33 |
| Last Modified: | 17 Aug 2022 08:56 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/2211 |
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