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Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria

Jaworowski, A., Fernandes, L. A., Yosaatmadja, F., Feng, G., Mwapasa, V., Molyneux, Malcolm E, Meshnick, S. R., Lewis, J. and Rogerson, S. J. (2009) 'Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria'. Clinical and Vaccine Immunology, Vol 16, Issue 3, pp. 312-319.

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Abstract

Human immunodeficiency virus type 1 (HIV-1) coinfection decreases antibodies to variant surface antigens implicated in pregnancy-associated malaria (VSA-PAM) caused by Plasmodium falciparum. The effect of HIV-1 on antibody functions that may protect mothers from pregnancy-associated malaria is unknown. Sera from multigravid pregnant women with malaria and HIV-1 coinfection (n = 58) or malaria alone (n = 29) and from HIV-1-infected (n = 102) or -uninfected (n = 54) multigravidae without malaria were analyzed for anti-VSAPAM antibodies by flow cytometry, the ability to inhibit adhesion to chondroitin sulfate A, or to opsonize CS2-infected erythrocytes for phagocytosis by THP-1 cells. In women with malaria, anti-VSA-PAM levels correlated better with opsonic activity (r = 0.60) than with adhesion-blocking activity (r = 0.33). In univariate analysis, HIV-1 coinfection was associated with lower opsonic activity but not adhesion-blocking activity or anti-VSA-PAM levels. Malaria-infected women with anemia (hemoglobin levels of <11.0 g/dl) had lower opsonic activity than nonanemic women (P = 0.007) independent of HIV-1 status. By multivariate analysis, in malaria-infected women, anemia (but not HIV status) was associated with opsonic activity. In women without malaria, opsonic activity was not associated with either anemia or HIV-1 status. In multigravid pregnant women with malaria, impaired serum opsonic activity may contribute to anemia and possibly to the decreased immunity to pregnancy-associated malaria associated with HIV-1. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Item Type: Article
Uncontrolled Keywords: antibody chondroitin 4 sulfate fansidar hemoglobin membrane antigen opsonin adult anemia article controlled study correlation analysis erythrocyte female flow cytometry hemoglobin blood level human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection human tissue immunity malaria male mixed infection multivariate analysis opsonization phagocytosis pregnancy pregnant woman priority journal protein blood level serum univariate analysis Antibodies, Protozoan Antigens, Protozoan Antigens, Surface HIV HIV Infections Humans Infant, Newborn Malaria, Falciparum Opsonin Proteins Plasmodium falciparum Pregnancy Complications, Infectious
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General)
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QY Clinical Pathology > Blood. Blood Chemistry > QY 450 Blood chemistry
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 312 Hemorrhagic disorders (General)
WQ Obstetrics > Pregnancy Complications > WQ 252 Hematologic complications
WQ Obstetrics > Pregnancy Complications > WQ 256 Infectious diseases
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1128/CVI.00356-08
Depositing User: Users 43 not found.
Date Deposited: 24 Jun 2010 11:34
Last Modified: 06 Feb 2018 12:59
URI: http://archive.lstmed.ac.uk/id/eprint/291

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