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Kazanidou, A., Nikou, Dimitra, Grigoriou, M., Vontas, John and Skavdis, G. (2009) 'Short Report: A Multiplex PCR Assay for Simultaneous Genotyping of kdr and ace-1 Loci in Anopheles gambiae'. American Journal of Tropical Medicine and Hygiene, Vol 80, Issue 2, pp. 236-238.
Full text not available from this repository.Abstract
The selection of insecticide-resistant genotypes in Anopheles gambiae, the most important malaria vector in Africa, makes disease control problematic in several endemic areas. The early detection and monitoring of resistance associated mutations in field mosquito populations is essential for the application of successful insecticide-based control interventions. Currently, the surveillance of these mutations is performed using individual assays, some of which require sophisticated and expensive equipment. Here we describe a novel multiplex polymerase chain reaction-based assay for detecting simultaneously the five single nucleotide polymorphisms in the voltage-gated sodium channel and the ace-l genes, which have been associated with the mosquito response to most commonly used insecticides.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | knockdown resistance kdr insecticide resistance mosquito vectors mutation identification populations arabiensis east ddt |
| Subjects: | WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 515 Anopheles |
| Faculty: Department: | Groups (2002 - 2012) > Vector Group |
| Depositing User: | Users 183 not found. |
| Date Deposited: | 27 Apr 2010 15:33 |
| Last Modified: | 06 Feb 2018 12:59 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/296 |
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