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The Wolbachia Bacterial Endosymbionts of Filarial Nematodes

Foster, Jeremy M., Hoerauf, Achim, Slatko, Barton E. and Taylor, Mark (2013) 'The Wolbachia Bacterial Endosymbionts of Filarial Nematodes' in: Kennedy, M.W. and Harnett, W., (eds) Parasitic nematodes: molecular biology, biochemistry and immunology, Wallingford, CABI, pp. 308-336.

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Abstract

This chapter discusses the symbiotic relationship between Wolbachia and filarial nematodes as indicated by antibiotic treatments and the combined analyses of the completed genomes of Wolbachia and its Brugia malayi host. Potential mechanisms that explain how Wolbachia activate innate and adaptive inflammatory responses associated with driving disease pathogenesis are described, as well as relevant molecular ligands and immunological pathways leading to disease pathogenesis.

Item Type: Book Section
Uncontrolled Keywords: antibacterial agents;drug therapy;endosymbionts;endosymbiosis;filariasis;genome analysis;human diseases;immune response;immune system;immunity;inflammation;molecular genetics;pathogenesis;tetracyclines; Brugia malayi;man;Wolbachia
Subjects: QU Biochemistry > Genetics > QU 550 Genetic techniques. PCR. Chromosome mapping
QV Pharmacology > Anti-Bacterial Agents. Tissue Extracts > QV 350 Anti-bacterial agents (General or not elsewhere classified)
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QX Parasitology > Helminths. Annelida > QX 301 Filarioidea
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1079/9781845937591.0000
Related URLs:
Depositing User: Julia Martin
Date Deposited: 02 Nov 2015 16:48
Last Modified: 06 Feb 2018 13:07
URI: http://archive.lstmed.ac.uk/id/eprint/4365

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