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Mathematical Models of Human African Trypanosomiasis Epidemiology (Chapter 3)

Rock, Kat S., Stone, Chris M., Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X, Keeling, Matt J., Torr, Steve ORCID: https://orcid.org/0000-0001-9550-4030 and Chitnis, Nakul (2015) 'Mathematical Models of Human African Trypanosomiasis Epidemiology (Chapter 3)'. Advances in Parasitology, Vol 87, pp. 53-133.

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Abstract

Human African trypanosomiasis (HAT), commonly called sleeping sickness, is caused by Trypanosoma spp. and transmitted by tsetse flies (Glossina spp.). HAT is usually fatal if untreated and transmission occurs in foci across sub-Saharan Africa. Mathematical modelling of HAT began in the 1980s with extensions of the Ross–Macdonald malaria model and has since consisted, with a few exceptions, of similar deterministic compartmental models. These models have captured the main features of HAT epidemiology and provided insight on the effectiveness of the two main control interventions (treatment of humans and tsetse fly control) in eliminating transmission. However, most existing models have overestimated prevalence of infection and ignored transient dynamics. There is a need for properly validated models, evolving with improved data collection, that can provide quantitative predictions to help guide control and elimination strategies for HAT.

Item Type: Article
Additional Information: Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A
Subjects: QU Biochemistry > QU 26.5 Informatics. Automatic data processing. Computers
WA Public Health > WA 105 Epidemiology
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 705 Trypanosomiasis
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/bs.apar.2014.12.003
Depositing User: Carmel Bates
Date Deposited: 13 Mar 2015 15:42
Last Modified: 06 Feb 2018 13:09
URI: https://archive.lstmed.ac.uk/id/eprint/5010

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