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Novel inhibitors of the Plasmodium falciparum electron transport chain

Stocks, P.A., Barton, V., Antoine, T., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, P. M. (2014) 'Novel inhibitors of the Plasmodium falciparum electron transport chain'. Parasitology, Vol 141, Issue 1, pp. 50-65.

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Abstract

Due to an increased need for new antimalarial chemotherapies that show potency against Plasmodium falciparum, researchers are targeting new processes within the parasite in an effort to circumvent or delay the onset of drug resistance. One such promising area for antimalarial drug development has been the parasite mitochondrial electron transport chain (ETC). Efforts have been focused on targeting key processes along the parasite ETC specifically the dihydroorotate dehydrogenase (DHOD) enzyme, the cytochrome bc 1 enzyme and the NADH type II oxidoreductase (PfNDH2) pathway. This review summarizes the most recent efforts in antimalarial drug development reported in the literature and describes the evolution of these compounds.

Item Type: Article
Additional Information: Special Issue 01 (Symposia of the British Society for Parasitology volume 49 Emerging paradigms in anti-infective drug design)
Subjects: QU Biochemistry > Cells and Genetics > QU 350 Cellular structures
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > QV 38 Drug action.
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1017/S0031182013001571
Depositing User: Lynn Roberts-Maloney
Date Deposited: 14 May 2015 10:17
Last Modified: 06 Feb 2018 13:09
URI: http://archive.lstmed.ac.uk/id/eprint/5142

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