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Interpretation of subgroup analyses in systematic reviews: A tutorial

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Richardson, Martha, Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941 and Donegan, Sarah (2018) 'Interpretation of subgroup analyses in systematic reviews: A tutorial'. Clinical Epidemiology and Global Health. (In Press)

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Abstract

Authors of systematic reviews may perform subgroup analyses to investigate how treatment effect varies across different subgroups of patients or trials. Previous research has shown that Cochrane review authors do not sufficiently report their interpretation of subgroup analyses. Consequently, we developed a tutorial with the aim of improving the interpretation of subgroup analyses in reviews. We explain the importance of interpreting subgroup analyses, and demonstrate how to interpret subgroup analyses using theoretical examples and a real-life subgroup analysis with clinical context. Finally, we provide recommendations for the interpretation of subgroup analyses in systematic reviews.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 21.5 Allied health personnel. Allied health professions
W General Medicine. Health Professions > W 26.5 Informatics. Health informatics
WA Public Health > Statistics. Surveys > WA 900 Public health statistics
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.cegh.2018.05.005
Depositing User: Stacy Murtagh
Date Deposited: 13 Jun 2018 13:42
Last Modified: 24 May 2019 12:43
URI: http://archive.lstmed.ac.uk/id/eprint/8758

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