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Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors

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Adolfi, Adrianna and Lycett, Gareth ORCID: https://orcid.org/0000-0002-2422-053X (2018) 'Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors'. Current Opinion in Insect Science, Vol 30, pp. 8-18.

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Abstract

Anopheles is the only genus of mosquitoes that transmit human malaria and consequently the focus of large scale genome and transcriptome-wide association studies. Genetic tools to define the function of the candidate genes arising from these analyses are vital. Moreover, genome editing offers the potential to modify Anopheles population structure at local and global scale to provide complementary tools towards the ultimate goal of malaria elimination. Major breakthroughs in Anopheles genetic analysis came with the development of germline transformation and RNA interference technology. Yet, the field has been revolutionized again by precise genome editing now possible through site-specific nucleases. Here we review the components of the current genetic toolkit available to study Anopheles, focusing particularly on how these technical advances are used to gain insight into malaria transmission and the design of genetic methods to control Anopheles vectors.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.cois.2018.07.014
Depositing User: Stacy Murtagh
Date Deposited: 10 Aug 2018 14:35
Last Modified: 26 Jul 2019 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/8983

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