Adolfi, Adrianna and Lycett, Gareth ORCID: https://orcid.org/0000-0002-2422-053X (2018) 'Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors'. Current Opinion in Insect Science, Vol 30, pp. 8-18.
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Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
Anopheles is the only genus of mosquitoes that transmit human malaria and consequently the focus of large scale genome and transcriptome-wide association studies. Genetic tools to define the function of the candidate genes arising from these analyses are vital. Moreover, genome editing offers the potential to modify Anopheles population structure at local and global scale to provide complementary tools towards the ultimate goal of malaria elimination. Major breakthroughs in Anopheles genetic analysis came with the development of germline transformation and RNA interference technology. Yet, the field has been revolutionized again by precise genome editing now possible through site-specific nucleases. Here we review the components of the current genetic toolkit available to study Anopheles, focusing particularly on how these technical advances are used to gain insight into malaria transmission and the design of genetic methods to control Anopheles vectors.
Item Type: | Article |
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Subjects: | QU Biochemistry > Genetics > QU 450 General Works QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors |
Faculty: Department: | Biological Sciences > Vector Biology Department |
Digital Object Identifer (DOI): | https://doi.org/10.1016/j.cois.2018.07.014 |
Depositing User: | Stacy Murtagh |
Date Deposited: | 10 Aug 2018 14:35 |
Last Modified: | 22 Aug 2019 11:03 |
URI: | https://archive.lstmed.ac.uk/id/eprint/8983 |
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