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Genetic characterization of Mycobacterium tuberculosis complex isolates circulating in Abuja, Nigeria

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Molina-Moya, Barbara ORCID: https://orcid.org/0000-0001-5144-2165, Abdurrahman, Saddiq T, Madukaji, Laura I, Kiréopori Gomgnimbou, Michel, Spinasse, Lizania, Gomes-Fernandes, Meissiner, Magdinier Gomes, Harrison, Kacimi, Sarah, Dacombe, Russell ORCID: https://orcid.org/0000-0002-6705-1537, Bimba, John S, Lawson, Lovett, Sola, Christophe, Cuevas, Luis E ORCID: https://orcid.org/0000-0002-6581-0587 and Dominguez, Jose (2018) 'Genetic characterization of Mycobacterium tuberculosis complex isolates circulating in Abuja, Nigeria'. Infection and Drug Resistance, Vol Volume 2018:, Issue 11, pp. 1617-1625.

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Abstract

Objective: Nigeria ranks fourth among the high tuberculosis (TB) burden countries. This study describes the prevalence of drug resistance and the genetic diversity of Mycobacterium tuberculosis in Abuja’s Federal Capital Territory.
Materials and methods: Two hundred and seventy-eight consecutive sputum samples were collected from adults with presumptive TB during 2013–2014. DNA was extracted from Löwenstein–Jensen cultures and analyzed for the identification of nontuberculous mycobacteria species, detection of drug resistance with line probe assays, and high-throughput spacer oligonucleotide typing (spoligotyping) using microbead-based hybridization.

Item Type: Article
Subjects: QW Microbiology and Immunology > QW 4 General works. Classify here works on microbiology as a whole.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QW Microbiology and Immunology > QW 50 Bacteria (General). Bacteriology. Archaea
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.2147/IDR.S166986
Depositing User: Stacy Murtagh
Date Deposited: 11 Oct 2018 15:20
Last Modified: 12 Oct 2018 08:48
URI: https://archive.lstmed.ac.uk/id/eprint/9451

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