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Var gene expression on human Plasmodium pathogenesis

Tembo, Dumizulu and Montgomery, Jacqui (2010) 'Var gene expression on human Plasmodium pathogenesis'. Future Microbiology, Vol 5, Issue 5, pp. 801-815.

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Plasmodium falciparum is responsible for most of the morbidity and mortality associated with malaria and is unique in its ability to sequester in organ postcapillary venules. Specific host-parasite interactions mediate this phenomenon and the P. falciperum erythrocyte membrane protein 1 is the predominant ligand responsible for adhering to host endothelial receptors. This review focuses on the current knowledge regarding this protein family, evidence for its role in various pathogenic mechanisms and on insights that have been gained in this area from field studies.

Item Type: Article
Uncontrolled Keywords: cytoadherence, falciparum, malaria, pathogenesis, PfEMP, Plasmodium, sequestration, var
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI):
Depositing User: Users 43 not found.
Date Deposited: 07 Sep 2010 09:47
Last Modified: 17 Jul 2020 10:57


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