Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children

Smith, Courtney, McLachlan, Georgia, Al Shehri, Hajri, Adriko, Moses, Arinaitwe, Moses, Atuhaire, Aaron, Tukahebwa, Edridah Muheki, LaCourse, E. James ORCID: https://orcid.org/0000-0001-9261-7136, Stanton, Michelle, Stothard, J. Russell ORCID: https://orcid.org/0000-0002-9370-3420 and Bustinduy, Amaya L. (2019) 'Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children'. American Journal of Tropical Medicine and Hygiene, Vol 100, Issue 6, pp. 1498-1506.

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Abstract

Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether Schistosoma mansoni infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset (n = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg−1 min−1 (interquartile range: 42.9–48.0 mL kg−1 min−1). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg−1 min−1, P = 0.031). The prevalence of stunting, wasting, S. mansoni egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg−1 min−1, P < 0.001). Multivariable-adjusted analysis revealed a strong negative association between S. mansoni egg patent infection and VO2max at low altitude (beta coefficient: −3.96, 95% CI: −6.56 to −137, P = 0.004). This is the first study to document a negative association between S. mansoni infection and aerobic capacity at low altitudes using the 20mSRT.

Item Type:	Article
Subjects:	QS Anatomy > QS 4 General works. Classify here works on regional anatomy QX Parasitology > Helminths. Annelida > QX 355 Schistosoma WA Public Health > WA 20.5 Research (General) WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WG Cardiovascular System > WG 100 General works WS Pediatrics > WS 20 Research (General)
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.4269/ajtmh.18-0922
Depositing User:	Stacy Murtagh
Date Deposited:	02 May 2019 12:53
Last Modified:	15 Apr 2020 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/10751

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