LSTM Home > LSTM Research > LSTM Online Archive

Estimating regional centile curves from mixed data sources and countries

Van Buuren, Stef, Hayes, Daniel, Stasinopoulos, D. Mikis, Rigby, Robert A, terKuile, Feiko ORCID: and Terlouw, Anja ORCID: (2009) 'Estimating regional centile curves from mixed data sources and countries'. Statistics in Medicine, Vol 28, pp. 2891-2911.

[img] Text
Terlouw_DJ_2009_Stat_Med_submitted_to_Journal_version.pdf - Submitted Version

Download (1MB)


Regional or national growth distributions can provide vital information on the health status of populations. In most resource poor countries, however, the required anthropometric data from purpose-designed growth surveys are not readily available. We propose a practical method for estimating regional (multi-country) age-conditional weight distributions based on existing survey data from different countries. We developed a two-step method by which one is able to model data with widely different age ranges and sample sizes. The method produces references both at the country level and at the regional (multi-country) level. The first step models country-specific centile curves by Box-Cox t and Box-Cox power exponential distributions implemented in generalized additive model for location, scale and shape through a common model. Individual countries may vary in location and spread. The second step defines the regional reference from a finite mixture of the country distributions, weighted by population size. To demonstrate the method we fitted the weight-for-age distribution of 12 countries in South East Asia and the Western Pacific, based on 273 270 observations. We modeled both the raw body weight and the corresponding Z score, and obtained a good fit between the final models and the original data for both solutions. We briefly discuss an application of the generated regional references to obtain appropriate, region specific, age-based dosing regimens of drugs used in the tropics. The method is an affordable and efficient strategy to estimate regional growth distributions where the standard costly alternatives are not an option. Copyright (c) 2009 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: The definitive version is available at
Uncontrolled Keywords: body weight; Asia; GAMLSS; centile estimation; mixture model; worm plot
Subjects: WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WS Pediatrics > Child Care. Nutrition. Physical Examination > WS 141 Physical examination. Diagnosis. Mass screening. Monitoring
Digital Object Identifer (DOI):
Depositing User: Helen Wong
Date Deposited: 13 Aug 2010 13:23
Last Modified: 14 Dec 2021 10:15


View details

Actions (login required)

Edit Item Edit Item