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Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

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Kay, Alexander W, González Fernández, Lucia, Takwoingi, Yemisi, Eisenhut, Michael, Vu, Ryan D, Steingart, Karen, Detjen, Anne K and Mandalakas, Anna M (2019) 'Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children'. Cochrane Database of Systematic Reviews, Vol 6, CD013359.

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Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:
Primary objectives

To determine the diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for a) PTB in children presumed to have tuberculosis; b) lymph node tuberculosis in children presumed to have tuberculosis; c) tuberculous meningitis in children presumed to have tuberculosis; and d) rifampicin resistance in children presumed to have tuberculosis.
For tuberculosis detection, the role of the index tests would be a replacement for standard practice.
For rifampicin resistance detection, the role of the index tests would be an initial replacement test for culture‐based drug susceptibility testing.

Item Type: Article
Subjects: WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 310 Therapy
WF Respiratory System > Lungs > WF 600 Lungs
WS Pediatrics > WS 100 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1002/14651858.CD013359
SWORD Depositor: JISC Pubrouter
Depositing User: Stacy Murtagh
Date Deposited: 01 Jul 2019 12:59
Last Modified: 17 Jun 2020 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/11094

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