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Pneumococcal disease : a systematic review of health utilities, resource use, costs, and economic evaluations of interventions

Shiri, Tinevimbo ORCID:, Khan, Kamran, Keaney, Katherine, Mukherjee, Geetanjali, McCarthy, Noel D and Petrou, Stavros (2019) 'Pneumococcal disease : a systematic review of health utilities, resource use, costs, and economic evaluations of interventions'. Value In Health, Vol 22, Issue 11, pp. 1329-1344.

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Pneumococcal diseases cause substantial mortality, morbidity and economic burden. Evidence on data inputs for economic evaluations of interventions targeting pneumococcal disease is critical.
To summarise evidence on resource use, costs, health utilities and cost-effectiveness for pneumococcal disease and associated interventions to inform future economic analyses.
We searched MEDLINE, Embase, Web of Science, CINAHL, PsycInfo, Econlit and Cochrane databases for peer-reviewed in English studies on pneumococcal disease that reported health utilities using direct or indirect valuation methods, resource use, costs or cost-effectiveness of intervention programmes, and summarised the evidence descriptively.
We included 383 studies: 9 reporting health utilities, 131 resource use, 160 economic costs of pneumococcal disease, 95 both resource use and costs, and 178 economic evaluations of pneumococcal intervention programmes. Health state utility values ranged from 0 to 1 for both meningitis and otitis media, and from 0.3 to 0.7 for both pneumonia and sepsis. Hospitalisation was shortest for otitis media (range: 0.1 to 5 days) and longest for sepsis/septicaemia (6 to 48).
The main categories of costs reported were drugs, hospitalisation and household or employer costs. Resource use was reported in terms of hospital length of stay and number of contacts with general practitioners. Costs and resource use significantly varied between population ages,disease conditions and settings. Current vaccination programmes for both adults and children, antibiotic use and outreach programmes to promote vaccination, early disease detection and
educational programmes are cost-effective in most countries.
This study has generated a comprehensive repository of health economic evidence on pneumococcal disease that can be used to inform future economic evaluations of pneumococcal disease intervention programmes.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 74 Medical economics. Health care costs
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
Depositing User: Rachel Dominguez
Date Deposited: 23 Sep 2019 14:28
Last Modified: 12 Nov 2019 09:43


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