Tools
Tools
Fisher, Nicholas, Bray, Patrick, Ward, Stephen 
ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595
(2007)
'The malaria parasite type IINADH : quinone oxidoreductase: an alternative enzyme for an alternative lifestyle'. Trends in Parasitology, Vol 23, Issue 7, pp. 305-310.
Abstract
The operation of a type II NADH:quinone oxidoreductase (PfNDH2), also known as alternative Complex I, in the mitochondrion of the human malaria parasite, Plasmodium falciparum, has recently been described. Unlike the Complex I of typical mitochondria, type II NADH:quinone oxidoreductases do not have transmembrane domains and are not involved directly in proton (H+) pumping. Here, we present a predictive model of PfNDH2, describing putative NADH-, flavin- and quinone-binding sites, as well as a possible membrane 'anchoring' region. In addition, we hypothesize that the alternative Complex I is an evolutionary adaptation to a microaerophilic lifestyle enabling (proton) uncoupled oxidation of NADH. This adaptive feature has several advantages, including: (i) a reduction of proton 'back-pressure' in the absence of extensive ATP synthesis; (ii) a reduction of mitochondrial superoxide generation; and (iii) a mechanism for the deregulated oxidation of cytosolic NADH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | nadh-ubiquinone oxidoreductase plasmodium-falciparum oxidative-phosphorylation superoxide-production respiratory-chain electron-transfer escherichia-coli binding-sites complex-i mitochondria |
| Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria |
| Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.pt.2007.04.014 |
| Depositing User: | Ms Julia Martin |
| Date Deposited: | 01 Sep 2010 11:10 |
| Last Modified: | 17 Jul 2020 10:57 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1193 |
Statistics
Actions (login required)
 |
Edit Item |