Molecular markers as indicators of antimalarial drug failure rates

Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X (2007) 'Molecular markers as indicators of antimalarial drug failure rates'. Tropical Medicine & International Health, Vol 12, Issue 11, pp. 1298-1301.

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Abstract

Several mutations have been identified in Plasmodium falciparum that cause, or contribute to, drug resistance. It is relatively easy to measure their prevalence in human blood samples, so they are often used to infer drug failure rates, clinical and parasitological, that will occur in the human population. One current method of making this inference is through the use of genotypic resistance and genotypic failure indices. These indices are rather sensitive to background drug failures rates (i.e. failures not caused by the mutation), to mutation prevalence, and to the genetic background in which the marker occurs. Extreme care should therefore be taken in the construction and interpretation of these indices.

Item Type:	Article
Additional Information:	Summary in English, French and Spanish.
Uncontrolled Keywords:	malaria drug resistance gfi gri molecular markers falciparum dihydrofolate-reductase plasmodium-falciparum sulfadoxine-pyrimethamine dihydropteroate synthase chloroquine resistance malaria mutations t76
Subjects:	QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified. QX Parasitology > Protozoa > QX 135 Plasmodia
Faculty: Department:	Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):	https://doi.org/10.1111/j.1365-3156.2007.01928.x
Depositing User:	Ms Julia Martin
Date Deposited:	02 Sep 2010 13:00
Last Modified:	19 Sep 2019 11:28
URI:	https://archive.lstmed.ac.uk/id/eprint/1207

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