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Plasmodium falciparum intercellular adhesion molecule-1-based cytoadherence-related signaling in human endothelial cells

Jenkins, N., Wu, Yang, Chakravorty, S., Kai, Oscar, Marsh, Kevin and Craig, Alister ORCID: (2007) 'Plasmodium falciparum intercellular adhesion molecule-1-based cytoadherence-related signaling in human endothelial cells'. Journal of Infectious Disease, Vol 196, Issue 2, pp. 321-327.

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Background. Cytoadherence of Plasmodium falciparum - infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the mechanisms underlying disease are poorly understood.
Methods. We compared parasite lines varying in their binding properties to human endothelial cells for their ability to stimulate signaling activity.
Results. In human umbilical vein endothelial cells ( HUVECs), which rely on adhesion to intercellular adhesion molecule ( ICAM) - 1 for binding, signaling is related to the avidity of the parasite line for ICAM- 1 and can be blocked either through the use of anti - ICAM- 1 monoclonal antibodies or HUVECs with altered ICAM- 1 binding properties ( i. e., ICAM- 1(Kilifi)). Human dermal microvascular endothelial cells ( HDMECs), which can bind infected erythrocytes via ICAM- 1 and CD36, have a more complex pattern of signaling behavior, but this is also dependent on adhesive interactions rather than merely contact between cells.
Conclusions. Signaling via apposition of P. falciparum - infected erythrocytes with host endothelium is dependent, at least in part, on the cytoadherence characteristics of the invading isolate. An understanding of the postadhesive processes produced by cytoadherence may help us to understand the variable pathologies seen in malaria disease.

Item Type: Article
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
QX Parasitology > QX 45 Host-parasite relations
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Digital Object Identifer (DOI):
Depositing User: Ms Julia Martin
Date Deposited: 21 Sep 2010 08:39
Last Modified: 17 Jul 2019 14:13


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