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Haemostatic Changes in Five Patients Infected with Ebola Virus

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Smither, Sophie, O’Brien, Lyn, Eastaugh, Lin, Woolley, Tom, Lever, Mark, Fletcher, Tom, Parmar, Kiran, Hunt, Beverley, Watts, Sarah and Kirkman, Emrys (2019) 'Haemostatic Changes in Five Patients Infected with Ebola Virus'. Viruses, Vol 11, Issue 7, p. 647.

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Abstract

Knowledge on haemostatic changes in humans infected with Ebola virus is limited due to safety concerns and access to patient samples. Ethical approval was obtained to collect plasma samples from patients in Sierra Leone infected with Ebola virus over time and samples were analysed for clotting time, fibrinogen, and D-dimer levels. Plasma from healthy volunteers was also collected by two methods to determine effect of centrifugation on test results as blood collected in Sierra Leone was not centrifuged. Collecting plasma without centrifugation only affected D-dimer values. Patients with Ebola virus disease had higher PT and APTT and D-dimer values than healthy humans with plasma collected in the same manner. Fibrinogen levels in patients with Ebola virus disease were normal or lower than values measured in healthy people. Clotting times and D-dimer levels were elevated during infection with Ebola virus but return to normal over time in patients that survived and therefore could be considered prognostic. Informative data can be obtained from plasma collected without centrifugation which could improve patient monitoring in hazardous environments

Item Type: Article
Subjects: WC Communicable Diseases > Virus Diseases > General Virus Diseases > WC 500 Virus diseases (General or not elsewhere classified)
WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 534 Viral hemorrhagic fevers
WH Hemic and Lymphatic Systems > WH 100 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.3390/v11070647
Depositing User: Stacy Murtagh
Date Deposited: 01 Oct 2019 13:13
Last Modified: 21 Nov 2019 14:06
URI: https://archive.lstmed.ac.uk/id/eprint/12601

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