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Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance

Ward, Stephen ORCID:, Sevene, E. J. P., Hastings, Ian ORCID:, Nosten, F. and McGready, R. (2007) 'Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance'. Lancet Infectious Diseases, Vol 7, Issue 2, pp. 136-144.

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Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have mechanisms in place to monitor risk during treatment. This requires data on drug disposition during pregnancy and potential toxicological liabilities to the developing fetus and mother. In most cases this information is not available. We review the reproductive toxicology of the main antimalarial drug classes in use or under development. Preclinical data are presented if appropriate, but as human experience overrides such data, in instances in which preclinical studies do not correlate with the human experience the data are reviewed only briefly. Additionally, we highlight the lack of appropriate drug disposition data in pregnancy and suggest mechanisms that can be used to capture data on risk after drug treatment in pregnancy.

Item Type: Article
Uncontrolled Keywords: uncomplicated falciparum-malaria resistant plasmodium-falciparum artesunate-atovaquone-proguanil sulfadoxine-pyrimethamine randomized-trial chloroquine therapy women quinine toxicity rat
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > Toxicology > General Toxicology > QV 600 General works
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI):
Depositing User: Ms Julia Martin
Date Deposited: 06 Dec 2010 10:41
Last Modified: 19 Sep 2019 11:28


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