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GRADE guidelines 26: Informative statements to communicate the findings of systematic reviews of interventions

Santesso, Nancy, Glenton, Claire, Dahm, Philipp, Garner, Paul ORCID:, Akl, Elie, Alper, Brian, Brignardello-Petersen, Romina, Carrasco-Labra, Alonso, De Beer, Hans, Hultcrantz, Monica, Kuijpers, Ton, Meerpohl, Joerg, Morgan, Rebecca, Mustafa, Reem, Skoetz, Nicole, Shahnaz, Sultan, Wiysonge, Charles, Guyatt, Gordon and Schünemann, Holger J (2020) 'GRADE guidelines 26: Informative statements to communicate the findings of systematic reviews of interventions'. Journal of Clinical Epidemiology, Vol 119, pp. 126-135.

GRADE narrative statements pre proof plus appendices 20191208.pdf - Accepted Version
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Objectives: Clear communication of systematic review findings will help readers and decision makers. We built on previous work to develop an approach that improves the clarity of statements to convey findings and that draws on Grading of Recommendations Assessment,
Development and Evaluation (GRADE).

Study Design and Setting: We conducted workshops including 80 attendants and a survey of 110 producers and users of systematic reviews. We calculated acceptability of statements and
revised the wording of those that were unacceptable to ≥40% of participants.

Results: Most participants agreed statements should be based on size of effect and certainty of evidence. Statements for low, moderate and high certainty evidence were acceptable to >60%. Key guidance, for example, includes statements for high, moderate and low certainty for a large effect on intervention x as: x results in a large reduction…; x likely results in a large reduction…; x may result in a large reduction…, respectively.

Conclusions: Producers and users of systematic reviews found statements to communicate findings combining size and certainty of an effect acceptable. This article provides GRADE guidance and a wording template to formulate statements in systematic reviews and other
decision tools.

Keywords: review literature as topic, health communication, Evidence-Based Medicine, Surveys and Questionnaires, Language, persuasive communication

Item Type: Article
Subjects: W General Medicine. Health Professions > W 20.5 Biomedical research
WA Public Health > Statistics. Surveys > WA 950 Theory or methods of medical statistics. Epidemiologic methods
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Christianne Esparza
Date Deposited: 09 Dec 2019 14:18
Last Modified: 08 Apr 2020 13:52


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