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Abong, Jovilia, Dalay, Victoria, Langley, Ivor 
ORCID: https://orcid.org/0000-0002-9275-6731, Tomeny, Ewan ORCID: https://orcid.org/0000-0003-4547-2389, Marcelo, Danaida, Mendoza, Victor, Aquino, Arvin, Garfin, Anna, Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038 and Yu, Charles
(2019)
'Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases'. PLoS ONE, Vol 14, Issue 12, e0227093.
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Abstract
Setting
A high proportion of notified tuberculosis cases in the Philippines are clinically diagnosed (63%) as opposed to bacteriologically confirmed. Better understanding of this phenomenon is required to improve tuberculosis control.
Objectives
To determine the percentage of smear negative presumptive tuberculosis patients that would be diagnosed by GeneXpert; compare clinical characteristics of patients diagnosed as tuberculosis cases; and review the impact that the current single government physician and a reconstituted Tuberculosis Diagnostic committee (expert panel) may have on tuberculosis over-diagnosis.
Design
This a cross-sectional study of 152 patients 15–85 years old with two negative Direct Sputum Smear Microscopy results, with abnormal chest X-ray who underwent GeneXpert testing and review by an expert panel.
Results
Thirty-two percent (48/152) of the sample were Xpert positive and 93% (97/104) of GeneXpert negatives were clinically diagnosed by a single physician. Typical symptoms and X-ray findings were higher in bacteriologically confirmed tuberculosis. When compared to the GeneXpert results the Expert panel’s sensitivity for active tuberculosis was high (97.5%, 39/40), specificity was low (40.2%, 35/87).
Conclusion
Using the GeneXpert would increase the level of bacteriologically confirmed tuberculosis substantially among presumptive tuberculosis. An expert panel will greatly reduce over-diagnosis usually seen when a decision is made by a single physician.
| Item Type: | Article |
|---|---|
| Subjects: | QY Clinical Pathology > Diagnostic Tests > QY 120 Sputum QY Clinical Pathology > QY 25 Laboratory techniques and procedure WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1371/journal.pone.0227093 |
| Depositing User: | Joy Gilroy |
| Date Deposited: | 14 Jan 2020 16:21 |
| Last Modified: | 16 Jan 2020 13:55 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/13521 |
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