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Exploiting insect-specific viruses as a novel strategy to control vector-borne disease

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Patterson, Ian ORCID: https://orcid.org/0000-0003-3465-0848, Villinger, Jandouwe, Muthoni, Joseph N, Dobel-Ober, Lucien and Hughes, Grant ORCID: https://orcid.org/0000-0002-7567-7185 (2020) 'Exploiting insect-specific viruses as a novel strategy to control vector-borne disease'. Current Opinion in Insect Science, Vol 39, pp. 50-56.

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

Novel insect-specific viruses (ISVs) are being discovered in many important vectors due to advances in sequencing technology and a growing awareness of the virome. Several in vitro and in vivo studies indicate that ISVs are capable of modulating pathogenic arboviruses. In addition, there is growing evidence that both vertical and horizonal transmission strategies maintain ISVs in vector populations. As such there is potential to exploit ISVs for stand-alone vector control strategies and deploying them in synergy with other symbiont control approaches such as Wolbachia-mediated control. However, before the applied potential can be realized, a greater understanding of their basic biology is required, including their species range, ability to be maintained and transmitted in native
and non-native vector hosts, and the effect of infection on a range of pathogens

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology QW Microbiology and Immunology > Viruses > QW 162 Insect viruses QX Parasitology > Arthropods > QX 460 Arthropods QX Parasitology > Insects. Other Parasites > QX 500 Insects
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.cois.2020.02.005
Depositing User:	Mel Finley
Date Deposited:	03 Mar 2020 14:09
Last Modified:	28 Feb 2021 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/13882

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