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Type II and type IV toxin–antitoxin systems show different evolutionary patterns in the global Klebsiella pneumoniae population

Horesh, Gal, Fino, Cinzia, Harms, Alexander, Dorman, Mathew J, Parts, Leopold, Gerdes, Kenn, Heinz, Eva ORCID: and Thomson, Nicholas Robert (2020) 'Type II and type IV toxin–antitoxin systems show different evolutionary patterns in the global Klebsiella pneumoniae population'. Nucleic Acids Research, Vol 48, Issue 8, pp. 4357-4370.

NAR-02217-Z-2019.R1 - Eva Heinz March 2020.pdf - Accepted Version
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The Klebsiella pneumoniae species complex includes important opportunistic pathogens which have become public health priorities linked to major hospital outbreaks and the recent emergence of multidrug-resistant hypervirulent strains. Bacterial virulence and the spread of multidrug resistance have previously been linked to toxin-antitoxin (TA) systems. TA systems encode a toxin that disrupts essential cellular processes, and a cognate antitoxin which counteracts this activity. Whilst associated with the maintenance of plasmids, they also act in bacterial immunity and antibiotic tolerance. However, the evolutionary dynamics and distribution of TA systems in clinical pathogens are not well understood. Here we present a comprehensive survey and description of the diversity of TA systems in 259 clinically relevant genomes of K. pneumoniae. We show that TA systems are highly prevalent with a median of 20 loci per strain. Importantly, these toxins differ substantially in their distribution patterns and in their range of cognate antitoxins. Classification along these properties suggests different roles of TA systems and
highlights the association and co-evolution of toxins and antitoxins.

Item Type: Article
Subjects: QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
WA Public Health > WA 20.5 Research (General)
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):
Depositing User: Mel Finley
Date Deposited: 02 Apr 2020 15:22
Last Modified: 10 Aug 2020 10:41


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