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Antibiotic prophylaxis for operative vaginal delivery

Liabsuetrakul, Tippawan, Choobun, Thanapan, Peeyananjarassri, Krantarat and Islam, Monir (2020) 'Antibiotic prophylaxis for operative vaginal delivery'. Cochrane Database of Systematic Reviews, Issue 3, CD004455.pub5.

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Vacuum and forceps assisted vaginal deliveries are reported to increase the incidence of postpartum infections and maternal readmission to hospital compared to spontaneous vaginal delivery. Prophylactic antibiotics may be prescribed to prevent these infections. However, the benefit of antibiotic prophylaxis for operative vaginal deliveries is still unclear. This is an update of a review last published in 2017.

To assess the effectiveness and safety of antibiotic prophylaxis in reducing infectious puerperal morbidities in women undergoing operative vaginal deliveries including vacuum or forceps delivery, or both.

Search methods
For this update, we searched Cochrane Pregnancy and Childbirth’s Trials Register,, the WHO International Clinical Trials Registry Platform (ICTRP) (5 July 2019), and reference lists of retrieved studies.

Selection criteria
All randomised controlled trials comparing any prophylactic antibiotic regimens with placebo or no treatment in women undergoing vacuum or forceps deliveries were eligible. Participants were all pregnant women without evidence of infections or other indications for antibiotics of any gestational age. Interventions were any antibiotic prophylaxis (any dosage regimen, any route of administration or at any time during delivery or the puerperium).

Data collection and analysis
Two review authors assessed trial eligibility and risk of bias. Two review authors extracted the data independently using prepared data extraction forms. Any discrepancies were resolved by discussion and a consensus reached through discussion with all review authors. We assessed methodological quality of the two included studies using the GRADE approach.

Item Type: Article
Subjects: QV Pharmacology > Anti-Bacterial Agents. Tissue Extracts > QV 350 Anti-bacterial agents (General or not elsewhere classified)
QV Pharmacology > QV 38 Drug action.
WQ Obstetrics > WQ 100 General works
WQ Obstetrics > Labor > WQ 300 General works
Faculty: Department: Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 31 Mar 2020 13:06
Last Modified: 26 Mar 2021 02:02


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