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Arguedas, Adriano, Trzciński, Trzciński Krzysztof, O’Brien, Katherine, Ferreira, Daniela 
ORCID: https://orcid.org/0000-0002-0594-0902, Wyllie, Anne, Weinberger, Daniel, Danon, Leon, Pelton, Stephen, Azzari, Chiara, Hammitt, Laura, Sá-Leão, Raquel, Brandileone, Maria-Cristina, Saha, Samir, Suaya, Jose, Isturiz, Raul, Jodar, Luis and Gessner, Bradford
(2020)
'Upper Respiratory Tract Colonization With Streptococcus pneumoniae in Adults'. Expert Review of Vaccines, Vol 19, Issue 4, pp. 353-366.
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Abstract
Introduction: Most of the current evidence regarding pneumococcal upper respiratory colonization in adults suggests that despite high disease burden, carriage prevalence is low. Contemporary studies on adult pneumococcal colonization have largely followed the pediatric approach by which samples are obtained mostly from the nasopharynx and bacterial detection is evaluated by routine culture alone. Recent evidence suggests that the ‘pediatric approach’ may be insufficient in adults and pneumococcal detection in this population may be improved by longitudinal studies that include samples from additional respiratory sites combined with more extensive laboratory testing.
Areas covered: In this article, relevant literature published in peer review journals on adult pneumococcal colonization, epidemiology, detection methods, and recommendations were reviewed.
Expert opinion: Respiratory carriage of Streptococcus pneumoniae has been underestimated in adults. Contemporary pneumococcal carriage studies in adults that collect samples from alternative respiratory sites such as the oropharynx, saliva, or nasal wash; are culture-enriched for pneumococcus; and use molecular diagnostic methods designed to target two pneumococcal DNA sequences should enhance pneumococcal detection in the adult respiratory tract. This finding may have implications for the interpretation of dynamics of pneumococcal transmission and vaccination.
| Item Type: | Article |
|---|---|
| Subjects: | QW Microbiology and Immunology > Bacteria > QW 142 Gram-positive bacteria (General) WF Respiratory System > WF 140 Diseases of the respiratory system (General) WF Respiratory System > WF 20 Research (General) |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1080/14760584.2020.1750378 |
| Depositing User: | Catherine Molloy |
| Date Deposited: | 23 Apr 2020 14:30 |
| Last Modified: | 17 Apr 2021 01:02 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/14305 |
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