Cooke, G. S., Tosh, K., Ramaley, P. A., Kaleebu, P., Zhuang, J., Nakiyingi, J. S., Watera, C., Gilks, C.F., French, Neil, Whitworth, J. A. G. and Hill, A. V. S. (2006) 'A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease'. Journal of Infectious Disease, Vol 194, Issue 5, pp. 666-669.
Full text not available from this repository.Abstract
We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.
Item Type: | Article |
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Subjects: | QU Biochemistry > Genetics > QU 450 General Works QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.3 Etiology. Transmission |
Digital Object Identifer (DOI): | https://doi.org/10.1086/505875 |
Depositing User: | Ms Julia Martin |
Date Deposited: | 22 Feb 2011 15:21 |
Last Modified: | 21 Nov 2019 14:47 |
URI: | https://archive.lstmed.ac.uk/id/eprint/1463 |
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