Guidelines for Diagnosing and Managing Disseminated Histoplasmosis among People Living with HIV

Murray, Marylou, Hine, Paul and Garner, Paul ORCID: https://orcid.org/0000-0002-0607-6941 (2020) 'Guidelines for Diagnosing and Managing Disseminated Histoplasmosis among People Living with HIV' in: Guidelines for diagnosing and managing disseminated histoplasmosis among people living with HIV, Washington DC, World Health Organization.

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Abstract

Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum . This disease is highly endemic in some regions of North America, Central America, and South America and is also reported in certain countries of Asia and Africa. It often affects people with impaired immunity, including people living with HIV, among whom the most frequent clinical presentation is disseminated histoplasmosis. The symptoms of disseminated histoplasmosis are non-specific and may be indistinguishable from those of other infectious diseases, especially disseminated tuberculosis (TB), thus complicating diagnosis and treatment. Histoplasmosis is one of the most frequent opportunistic infections caused by fungal pathogens among people living with HIV in the Americas and may be responsible for 5–15% of AIDS-related deaths every year in this Region. These guidelines aim to provide recommendations for the diagnosis, treatment, and management of disseminated histoplasmosis in persons living with HIV. Although the burden of disease is concentrated in the Americas, the recommendations contained within these guidelines are applicable globally. These guidelines were produced in accordance with the World Health Organization (WHO) handbook for guideline development. The Guideline Development Group elaborated the final recommendations based on systematic review of scientific literature and critical evaluation of the evidence available using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. These guidelines are intended for health-care providers, HIV program managers, policy-makers, national treatment advisory boards, and other professionals involved in caring for people who either have or may be at risk of developing disseminated histoplasmosis

Item Type:	Book Section
Corporate Authors:	Global HIV, Hepatitis and Sexually Transmitted Infections Programmes
Subjects:	WC Communicable Diseases > Mycoses > WC 465 Histoplasmosis WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Depositing User:	Christianne Esparza
Date Deposited:	02 Jul 2020 14:48
Last Modified:	03 Aug 2020 11:18
URI:	https://archive.lstmed.ac.uk/id/eprint/14834

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