Tools
Tools
Nyazika, Tinashe, Kaela, Rabelani, Mugoni, Mathias, Musomekwa, Kudakwashe, Kyei-Baafour, Eric, Chiwanda, Simbarashe, Mapondera, Prichard T., Makawa, Tatenda, Sithole, Elliot M, Mavunganidze, George, Manasa, Justen, Jambo, Kondwani 
ORCID: https://orcid.org/0000-0002-3195-2210 and Musarurwa, Cuthbert
(2020)
'Implementation of Antibody Rapid Diagnostic Testing versus
Real-Time Reverse Transcription-PCR Sample Pooling in the
Screening of COVID-19: a Case of Different Testing Strategies
in Africa'. mSphere, Vol 5, Issue 4, e00524-20.
|
Text
Nyazika mSphere.pdf - Accepted Version Available under License Creative Commons Attribution. Download (796kB) | Preview |
|
|
Text
mSphere-2020-Nyazika-e00524-20.full.pdf - Published Version Available under License Creative Commons Attribution. Download (292kB) | Preview |
Abstract
COVID-19 has wreaked havoc across the globe, although cases in Africa remain lower than 50 other regions but they are gradually on an upward trajectory. To date, COVID-19 cases have 51 been reported in 54 countries. However, due to limited SARS-COV-2 rRT-PCR testing 52 capacity and scarcity of testing reagents, it is probable that the total number of cases could 53 far exceed published statistics. In this viewpoint, using Ghana, Malawi, South Africa and 54 Zimbabwe as examples of countries that have implemented different testing strategies, we 55 argue that the implementation of sample pooling for rRT-PCR over antibody rapid diagnostic 56 testing could have a greater impact in assessing disease burden. Sample pooling offers huge 57 advantages compared to single test rRT-PCR, as it lowers experimental costs, personnel 58 time, reduces burnout and analytical run-times. Africa is already strained in terms of testing 59 resources for COVID-19, hence cheaper alternative ways need to be implemented to 60 conserve resources, maximise on mass testing and reduce transmission in the wider 61 population.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > WA 105 Epidemiology WA Public Health > Preventive Medicine > WA 243 Diagnositic services WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections |
| Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW) |
| Digital Object Identifer (DOI): | https://doi.org/10.1128/mSphere.00524-20 |
| Depositing User: | Stacy Murtagh |
| Date Deposited: | 10 Aug 2020 14:49 |
| Last Modified: | 28 Jul 2022 15:54 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/15130 |
Statistics
Actions (login required)
 |
Edit Item |