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Jenkins, N., Chakravorty, S., Urban, Britta 
ORCID: https://orcid.org/0000-0002-4197-8393, Kai, O. K., Marsh, K. and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164
(2006)
'The effect of Plasmodium falciparum infection on expression of monocyte surface molecules'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 100, Issue 11, pp. 1007-1012.
Abstract
Plasmodium falciparum infection may result in severe malaria in susceptible individuals. The pathogenesis of severe disease is probably a combination of the sequestration of infected erythrocytes and overstimulation of the immune response. Monocytes Eire a key source of many of the pro-inflammatory agents implicated but also are found sequestered in blood vessels. However, little is known about the monocyte phenotype in malaria disease. Flow cytometry was performed on fresh whole blood to determine surface expression of four receptors during acute severe and non-severe malaria and again during convalescence when uninfected. Three hundred and fifty-six children with P falciparum infection were studied and were found to show increased expression of intercellular adhesion molecule-1 (ICAM-1), urokinase plasminogen activator receptor (uPAR), CD23 and chemokine receptor 5 (CCR5) (P < 0.001) during acute disease compared with convalescent levels. Using multivariate analysis, it was found that large increases in expression of ICAM-1 (odds ratio (OR) 2.44, 95% CI 1.80-3.32) and uPAR (OR 3.14, 95% CI 1.93-5.09) but small increases in expression of CD23 (OR 0.82, 95% CI 0.68-0.96) were independently associated with severe malaria. These results give an insight into the cellular processes occurring in severe malaria and suggest that pathology is based on a complex repertoire of pro- and anti-inflammatory processes. (C) 2006 Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | malaria plasmodium falciparum icam-1 cd23 cd87 upar ccr5 monocytes human cerebral malaria plasminogen-activator receptor nitric-oxide production tumor-necrosis-factor endothelial activation adhesion molecule-1 disease severity urokinase children sequestration |
| Subjects: | QX Parasitology > Protozoa > QX 135 Plasmodia |
| Faculty: Department: | Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group |
| Digital Object Identifer (DOI): | https://doi.org/10.1016/j.trstmh.2006.01.005 |
| Depositing User: | Ms Julia Martin |
| Date Deposited: | 28 Jan 2011 14:17 |
| Last Modified: | 17 Jul 2019 14:13 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/1519 |
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