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Moyes, Catherine L., Athinya, Duncan K., Seethaler, Tara, Battle, Katherine E., Sinka, Marianne, Hadi, Melinda P., Hemingway, Janet 
ORCID: https://orcid.org/0000-0002-3200-7173, Coleman, Michael ORCID: https://orcid.org/0000-0003-4186-3526 and Hancock, Penelope A.
(2020)
'Evaluating insecticide resistance across African districts to aid malaria control decisions'. Proceedings of the National Academy of Sciences, Vol 117, Issue 36, pp. 22042-22050.
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Evaluating insecticide resistance across African districts to aid malaria control decisions.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
Abstract
Malaria vector control may be compromised by resistance to insecticides in vector populations. Actions to mitigate against resistance rely on surveillance using standard susceptibility tests, but there are large gaps in the monitoring data across Africa. Using a published geostatistical ensemble model, we have generated maps that bridge these gaps and consider the likelihood that resistance exceeds recommended thresholds. Our results show that this model provides more accurate next-year predictions than two simpler approaches. We have used the model to generate district-level maps for the probability that pyrethroid resistance in Anopheles gambiae s.l. exceeds the World Health Organization thresholds for susceptibility and confirmed resistance. In addition, we have mapped the three criteria for the deployment of piperonyl butoxide-treated nets that mitigate against the effects of metabolic resistance to pyrethroids. This includes a critical review of the evidence for presence of cytochrome P450-mediated metabolic resistance mechanisms across Africa. The maps for pyrethroid resistance are available on the IR Mapper website, where they can be viewed alongside the latest survey data.
| Item Type: | Article |
|---|---|
| Subjects: | WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by) WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1073/pnas.2006781117 |
| Depositing User: | Samantha Sheldrake |
| Date Deposited: | 01 Sep 2020 13:30 |
| Last Modified: | 28 Sep 2020 09:37 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/15448 |
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