Risk for tuberculosis among children

Nakaoka, H., Lawson, Lovett, Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Coulter, Brian, Ravn, P., Brock, I., Hart, C. Anthony and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2006) 'Risk for tuberculosis among children'. Emerging Infectious Diseases, Vol 12, Issue 9, pp. 1383-1388.

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Abstract

Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-gamma-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were > 10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.

Item Type:	Article
Uncontrolled Keywords:	cell-based assay linked immunospot assay mycobacterium-tuberculosis skin-test bcg vaccination infection gamma diagnosis responses contacts
Subjects:	QY Clinical Pathology > QY 4 General works WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases WA Public Health > WA 30 Socioeconomic factors in public health (General) WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 205 Epidemiology WF Respiratory System > Tuberculosis > WF 215 Pathology WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis WF Respiratory System > Tuberculosis > WF 415 Tuberculosis in childhood
Digital Object Identifer (DOI):	https://doi.org/10.3201/eid1209.051606
Depositing User:	Sarah Lewis-Newton
Date Deposited:	24 Feb 2011 16:16
Last Modified:	05 Dec 2024 14:08
URI:	https://archive.lstmed.ac.uk/id/eprint/1560

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