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Post-tuberculosis lung health: perspectives from the First International Symposium

Allwood, B. W., van der Zalm, M. M., Amaral, A. F. S., Byrne, A., Datta, S., Egere, Uzochukwu, Evans, C. A., Evans, D., Gray, D. M, Hoddinott, G., Ivanova, O., Jones, R., Makanda, G., Marx, F. M., Meghji, Jamilah ORCID: https://orcid.org/0000-0002-4693-8884, Mpagama, S., Pasipanodya, J. G., Rachow, A., Schoeman, I., Shaw, J., Stek, C., van Kampen, S., von Delft, D., Walker, Naomi ORCID: https://orcid.org/0000-0002-3345-7694, Wallis, R. S. and Mortimer, Kevin ORCID: https://orcid.org/0000-0002-8118-8871 (2020) 'Post-tuberculosis lung health: perspectives from the First International Symposium'. The International Journal of Tuberculosis and Lung Disease, Vol 24, Issue 8, pp. 820-828.

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Abstract

Tuberculosis, although curable, frequently leaves the individual with chronic physical and psycho-social impairment, yet these consequences have to-date been largely neglected.
The 1st International Post-Tuberculosis Symposium was devoted entirely to impairment after tuberculosis, and covered a number of multi-disciplinary topics. Using the Delphi process, consensus was achieved for the terms “post- tuberculosis”, “post-tuberculosis lung disease/s (PTLD)”, and “post-tuberculosis economic, social and psychological well-being” (Post-TB ESP)”, to overcome the historical challenge of varied terminology in the literature. A minimum case-definition was proposed by consensus for PTLD in adults and children. Lack of sufficient evidence hampered definitive recommendations in most domains, including prevention and treatment of PTLD, but highlighted the dire need for research and priorities were identified. The heterogeneity of respiratory outcomes and previously employed research methodologies complicates the accurate estimation of disease burden. However, consensus was reached proposing a toolkit for future PTLD measurement, and on PTLD patterns to be considered. The importance of extra-pulmonary consequences and progressive impairment throughout the life-course was identified, including tuberculosis recurrence and increased mortality. Patient advocates emphasised the need for addressing the psychological and social impacts post tuberculosis, and called for clinical guidance. Increased awareness and more research addressing post-tuberculosis complications is urgently needed.

Item Type: Article
Subjects: W General Medicine. Health Professions > W 20.5 Biomedical research
WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General)
WF Respiratory System > Tuberculosis > WF 205.1 General coverage
WF Respiratory System > Lungs > WF 600 Lungs
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI): https://doi.org/10.5588/ijtld.20.0067
Depositing User: Rachel Dominguez
Date Deposited: 01 Oct 2020 15:10
Last Modified: 01 Oct 2020 15:10
URI: https://archive.lstmed.ac.uk/id/eprint/15704

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