A comparative genomics multitool for scientific discovery and conservation

Consortium, Zoonomia and Casewell, Nicholas ORCID: https://orcid.org/0000-0002-8035-4719 (2020) 'A comparative genomics multitool for scientific discovery and conservation'. Nature, Vol 587, pp. 240-245.

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Abstract

The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.

Item Type:	Article
Subjects:	QU Biochemistry > Genetics > QU 450 General Works QU Biochemistry > Genetics > QU 460 Genomics. Proteomics
Faculty: Department:	Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41586-020-2876-6
Depositing User:	Mary Creegan
Date Deposited:	19 Nov 2020 12:46
Last Modified:	19 Nov 2020 12:46
URI:	https://archive.lstmed.ac.uk/id/eprint/16132

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