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Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations

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Ochodo, Eleanor A, Nelson, Kalema, Schumacher, Samuel, Steingart, Karen, Young, Taryn, Mallett, Susan, Deeks, Jon, Cobelens, Frank, Bossuyt, Patrick M, Nicol, Mark P and Cattamanchi, Adithya (2020) 'Variation in the observed effect of Xpert MTB/RIF testing for tuberculosis on mortality: A systematic review and analysis of trial design considerations'. Wellcome Open Research, Vol 4, Issue 173.

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Official URL: https://wellcomeopenresearch.org/articles/4-173

Abstract

Abstract
Background: Most studies evaluating the effect of Xpert MTB/RIF
testing for tuberculosis (TB) concluded that it did not reduce overall
mortality compared to usual care. We conducted a systematic review
to assess whether key study design and execution features
contributed to earlier identification of patients with TB and decreased
pre-treatment loss to follow-up, thereby reducing the potential impact
of Xpert MTB/RIF testing.

Item Type:	Article
Subjects:	WA Public Health > Statistics. Surveys > WA 900 Public health statistics WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.12688/wellcomeopenres.15412.2
Depositing User:	Christianne Esparza
Date Deposited:	28 Nov 2020 15:37
Last Modified:	28 Nov 2020 15:37
URI:	https://archive.lstmed.ac.uk/id/eprint/16188

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