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Risk of malaria in young children after periconceptional iron supplementation

Gies, Sabine, Roberts, Stephen A., Diallo, Salou, Lompo, Olga M., Tinto, Halidou and Brabin, Bernard (2020) 'Risk of malaria in young children after periconceptional iron supplementation'. Maternal And Child Nutrition, Vol 2020, e13106.

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This study in Burkina Faso investigated whether offspring of young mothers who had received weekly peri-conceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed. Data were available for 180 babies surviving to the time of the survey when their median age was 9 months. Prevalence of maternal iron deficiency in the last trimester based on low body iron stores was 16%. Prevalence of active placental malaria infection was 24.8%, past infection 59% and chorioamnionitis 55.6%. Babies of iron supplemented women had lower median gestational age. Four out of five children ≥ 6 months were iron deficient and 98% were anaemic. At four months malaria prevalence was 45%. Child iron biomarkers, anaemia and malaria outcomes did not differ by trial arm. Factors associated with childhood parasitaemia were third trimester C-reactive protein level (OR 2.1; 95%CI 1.1-3.9), active placental malaria (OR 5.8; 1.0-32.5, P=0.042) and child body iron stores (OR 1.13; 1.04-1.23, P=0.002). Chorioamnionitis was associated with reduced risk of child parasitaemia (OR 0.4; 0.1-1.0, P=0.038). Peri-conceptional iron supplementation of young women did not alter body iron stores of their children. Higher child body iron stores and placental malaria increased risk of childhood parasitaemia.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
WS Pediatrics > By Age Groups > WS 430 Infancy
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):
Depositing User: Stacy Murtagh
Date Deposited: 28 Nov 2020 16:10
Last Modified: 28 Nov 2020 16:10


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