Vanlandingham, D. L., Tsetsarkin, K., Klingler, K. A., Hong, C., McElroy, K. L., Lehane, Mike and Higgs, S. (2006) 'Determinants of vector specificity of o'nyong nyong and chikungunya viruses in Anopheles and Aedes mosquitoes'. American Journal of Tropical Medicine and Hygiene, Vol 74, Issue 4, pp. 663-669.
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DETERMINANTS_OF_VECTOR_SPECIFICITY_OF_O’NYONG_NYONG_AND.pdf - Published Version Download (513kB) |
Abstract
The alphaviruses o'nyong nyong virus (ONNV) and chikungunya virus (CHIKV) provide a unique system to study the viral genes involved in vector specificity. ONNV infects both anopheline and culicine mosquitoes, whereas CHIKV infects only culicine mosquitoes. In this study, chimeric viruses were constructed that contained genes from both ONNV and CHIKV. These chimeras and previously described full-length infectious clones of ONNV and CHIKV were evaluated in Anopheles gambiae and Aedes aegypti mosquitoes. Virus derived from the infectious clones of ONNV and CHIKV retained the vector specificity of the parental viruses. All six of the chimeras were found to infect Ae. aegypti mosquitoes at high rates but only the chimera containing viral genes encoding all of the structural proteins of ONNV was able to infect An. gambiae mosquitoes. These data indicate that all of the viral structural proteins are necessary for ONNV to infect An. gambiae mosquitoes.
Item Type: | Article |
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Uncontrolled Keywords: | fever aegypti glycoprotein alphaviruses replication reemergence emergence infection gambiae absence |
Subjects: | QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 525 Aedes QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors WC Communicable Diseases > Virus Diseases > Infectious Mononucleosis. Arbovirus Infections > WC 524 Arbovirus infections |
Faculty: Department: | Groups (2002 - 2012) > Vector Group |
Depositing User: | Sarah Lewis-Newton |
Date Deposited: | 02 Mar 2011 16:35 |
Last Modified: | 06 Feb 2018 13:02 |
URI: | https://archive.lstmed.ac.uk/id/eprint/1623 |
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