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Disease progression in patients with COVID-19: a retrospective cohort study in China

Luo, Huanyuan, Liu, S., Wang, Y., Mortimer, K., Ju, S., Yang, Y. and Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464 (2020) 'Disease progression in patients with COVID-19: a retrospective cohort study in China'. International Journal of Tuberculosis and Lung Disease, Vol 24, Issue 10, pp. 1032-1037.

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Abstract

OBJECTIVE: To evaluate the clinical features of disease progression among patients with COVID-19 to help early identification of patients at high risk.

DESIGN: This was a retrospective, multi-centre cohort study. From 10 January to 29 February 2020, all cases diagnosed with COVID-19 at 24 hospitals (with complete medical records) in Jiangsu Province, China were recruited. The primary outcome was deterioration in condition, i.e., the dramatic progression from asymptomatic or mild or moderate status into severe or critically ill status during 14 days´ follow-up.

RESULTS: Of the 625 patients in Jiangsu, none died; 597 patients were asymptomatic or had mild or moderate disease on admission, of whom 36 (6%) experienced disease deterioration to become severe or critically ill.

CONCLUSION: Disease deterioration to severe or critically ill status was associated with age, pulmonary opacity score, lymphocyte count on admission and exposure to the pandemic centre in Wuhan.

Item Type: Article
Subjects: WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 518 Respirovirus Infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.5588/ijtld.20.0386
Depositing User: Rachael O'Donoghue
Date Deposited: 08 Dec 2020 20:51
Last Modified: 01 Apr 2021 01:02
URI: https://archive.lstmed.ac.uk/id/eprint/16272

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