Bartholomay, L. C., Waterhouse, R. M., Mayhew, G. F., Campbell, C. L., Michel, K., Zou, Z., Ramirez, J. L., Das, S., Alvarez, K., Arensburger, P., Bryant, B., Chapman, S. B., Dong, Y., Erickson, S. M., Karunaratne, S. H. P. P., Kokoza, V., Kodira, C. D., Pignatelli, Patricia, Shin, S. W., Vanlandingham, D. L., Atkinson, P. W., Birren, B., Christophides, G. K., Clem, R. J., Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Higgs, S., Megy, K., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Zdobnov, E. M., Raikhel, A. S., Christensen, B. M., Dimopoulos, G. and Muskavitch, M. A. T. (2010) 'Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens'. Science, Vol 330, Issue 6000, pp. 88-90.
Full text not available from this repository.Abstract
The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
Item Type: | Article |
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Subjects: | QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance. QW Microbiology and Immunology > Immune Responses > QW 730 Virulence. Invasiveness QX Parasitology > Helminths. Annelida > QX 203 Nematoda QX Parasitology > Helminths. Annelida > QX 301 Filarioidea QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 515 Anopheles QX Parasitology > Insects. Other Parasites > QX 525 Aedes QX Parasitology > Insects. Other Parasites > QX 530 Culex |
Digital Object Identifer (DOI): | https://doi.org/10.1126/science.1193162 |
Depositing User: | Users 183 not found. |
Date Deposited: | 08 Oct 2010 11:39 |
Last Modified: | 24 Jan 2022 15:43 |
URI: | https://archive.lstmed.ac.uk/id/eprint/1659 |
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