Control of malaria-transmitting mosquitoes using gene drives

Nolan, Tony ORCID: https://orcid.org/0000-0002-2982-8333 (2021) 'Control of malaria-transmitting mosquitoes using gene drives'. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, Vol 376, Issue 1818.

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Abstract

Gene drives are selfish genetic elements that can be re-designed to invade a population and they hold tremendous potential for the control of mosquitoes that transmit disease. Much progress has been made recently in demonstrating proof of principle for gene drives able to suppress populations of malarial mosquitoes, or to make them refractory to the Plasmodium parasites they transmit. This has been achieved using CRISPR-based gene drives. In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control.

Item Type:	Article
Subjects:	QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control WC Communicable Diseases > Tropical and Parasitic Diseases > WC 680 Tropical diseases (General) WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department:	Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI):	https://doi.org/10.1098/rstb.2019.0803
Depositing User:	Samantha Sheldrake
Date Deposited:	14 Jan 2021 14:19
Last Modified:	14 Jan 2021 14:19
URI:	https://archive.lstmed.ac.uk/id/eprint/16658

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