Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults.

Michael, D R, Davies, T S, Jack, A A, Masetti, G, Marchesi, J R, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Mullish, B H and Plummer, S F (2021) 'Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults.'. Scientific reports, Vol 11, p. 5.

Preview	Text Daily supplementation with the Lab4P - weight loss in overweight adults - DWang.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview
	Text PROBE_Manuscript_Final - DWang.docx - Accepted Version Restricted to Repository staff only Download (122kB)

Abstract

This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45-65 years with BMI 25-29.9 kg/m received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, p < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, p < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, p < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.

Item Type:	Article
Subjects:	QU Biochemistry > Vitamins > QU 145 Nutrition. Nutritional requirements QU Biochemistry > Vitamins > QU 145.5 Nutritive values of food
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1038/s41598-020-78285-3
Depositing User:	Julie Franco
Date Deposited:	14 Jan 2021 13:25
Last Modified:	14 Jan 2021 13:25
URI:	https://archive.lstmed.ac.uk/id/eprint/16670

Statistics

View details

Actions (login required)

Edit Item