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Beyond accuracy: creating a comprehensive evidence base for tuberculosis diagnostic tools

Mann, Gillian, Squire, Bertie ORCID: https://orcid.org/0000-0001-7173-9038, Bissell, K., Eliseev, P., Du Toit, E., Hesseling, A., Nicol, M., Detjen, A. and Kritski, A. (2010) 'Beyond accuracy: creating a comprehensive evidence base for tuberculosis diagnostic tools'. International Journal of Tuberculosis and Lung Disease, Vol 14, Issue 12, pp. 1518-1524.

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Abstract

The need for a strong and comprehensive evidence base to support decision making with regard to the implementation of new and improved diagnostic tools and approaches has been highlighted by a number of stakeholders; these include members of the New Diagnostics Working Group (NDWG) and the Subgroup for Introducing New Approaches and Tools of the Stop TB Partnership. To compile such evidence in a systematic manner, we have developed an impact assessment framework (IAF) which links evidence on inputs to outcomes.

The IAF comprises five interconnected layers: effectiveness analysis, equity analysis, health systems analysis, scale-up analysis and policy analysis. It can be used by new diagnostics developers and other interested research teams to collect as much policy-relevant data as possible prior to, during and after the demonstration phase of tool development. The evidence collated may be used by international and national policy makers to support adoption, implementation and scale-up decisions. The TREAT TB (Technology, Research, Education and Technical Assistance for TB) initiative uses the IAF in its operational research and field evaluations of new tools and approaches for TB diagnosis. It has also been incorporated into the NDWG's recent publication: ‘Pathways to better diagnostics for tuberculosis: a blueprint for the development of TB diagnostics’. This article describes the IAF and the process of improving it and suggests next steps in overcoming the challenges in its implementation.

Item Type: Article
Subjects: WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Related URLs:
Depositing User: Helen Rigby
Date Deposited: 13 Dec 2010 16:02
Last Modified: 20 Nov 2024 12:29
URI: https://archive.lstmed.ac.uk/id/eprint/1700

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