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Beyond accuracy: creating a comprehensive evidence base for tuberculosis diagnostic tools

Mann, Gillian, Squire, Bertie ORCID:, Bissell, K., Eliseev, P., Du Toit, E., Hesseling, A., Nicol, M., Detjen, A. and Kritski, A. (2010) 'Beyond accuracy: creating a comprehensive evidence base for tuberculosis diagnostic tools'. International Journal of Tuberculosis and Lung Disease, Vol 14, Issue 12, pp. 1518-1524.

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The need for a strong and comprehensive evidence base
to support decision making with regard to the implementation
of new and improved diagnostic tools and
approaches has been highlighted by a number of stakeholders;
these include members of the New Diagnostics
Working Group (NDWG) and the Subgroup for Introducing
New Approaches and Tools of the Stop TB Partnership.
To compile such evidence in a systematic manner,
we have developed an impact assessment framework
(IAF) which links evidence on inputs to outcomes.
The IAF comprises fi ve interconnected layers: effectiveness
analysis, equity analysis, health systems analysis,
scale-up analysis and policy analysis. It can be used by
new diagnostics developers and other interested research
teams to collect as much policy-relevant data as possible
prior to, during and after the demonstration phase of
tool development. The evidence collated may be used by
international and national policy makers to support adoption,
implementation and scale-up decisions. The TREAT
TB (Technology, Research, Education and Technical Assistance
for TB) initiative uses the IAF in its operational
research and fi eld evaluations of new tools and approaches
for TB diagnosis. It has also been incorporated
into the NDWG’s recent publication: ‘Pathways to better
diagnostics for tuberculosis: a blueprint for the development
of TB diagnostics’. This article describes the IAF
and the process of improving it and suggests next steps
in overcoming the challenges in its implementation.
KEY WORDS: impact; evidence; tuberculosis; policy;

Item Type: Article
Subjects: WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Related URLs:
Depositing User: Helen Rigby
Date Deposited: 13 Dec 2010 16:02
Last Modified: 07 Jun 2022 11:09


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